📄 Category

psychiatry and clinical psychology

146 papers

Understanding the human mind and treating mental health conditions requires a deep blend of biological insight and behavioral science. This category explores the cutting-edge research shaping how we diagnose and treat psychiatric disorders, from depression and anxiety to complex neurological conditions. Here, you will find the latest discoveries that bridge the gap between clinical observation and molecular mechanisms, offering fresh perspectives on patient care and therapeutic innovation.

Gist.Science brings these vital studies directly to you by monitoring medRxiv, the leading preprint server for health sciences. As soon as new manuscripts appear in this field, our team processes them to provide both accessible plain-language summaries and detailed technical overviews. This ensures that complex findings are understandable for everyone, from curious readers to busy professionals who need quick, accurate insights without wading through dense academic prose.

Below are the most recent psychiatry and clinical psychology preprints, curated and summarized to keep you informed on the evolving landscape of mental health research.

📄 psychiatry and clinical psychology

Early DNA methylation at the NGFI-A binding site of the NR3C1 1F promoter predicts cognitive functions at age five: evidence from the Parents as Teachers intervention in the ZEPPELIN study

This study demonstrates that early DNA methylation at the NGFI-A binding site of the NR3C1 1F promoter predicts lower cognitive function at age five in children from disadvantaged backgrounds, a relationship mediated by concentration problems and modulated by early life stressors and the Parents as Teachers intervention.

Gardini, E. S., Neuhauser, A., Schaub, S., Kalkusch, I., Rodcharoen, P., Ehlert, U., Lanfranchi, A., Turecki, G., Klaver (…)2026-02-24
📄 psychiatry and clinical psychology

Network Analysis of Mental Well-being, Psychological Inflexibility, and Psychopathological Symptoms in Individuals Seeking Online Psychological Support

This cross-sectional study of 967 Mexican participants seeking online psychological support utilized network analysis to identify self-evaluation and emotional well-being as central elements linking mental well-being with distress and psychological inflexibility, thereby highlighting key targets for intervention.

Gonzalez-Ramirez, L. P., Gonzalez-Cantero, J. O., Martinez-Arriaga, R. J., Jimenez, S., Herdoiza-Arroyo, P. E., Robles-G (…)2026-02-24
📄 psychiatry and clinical psychology

The efficacy of internet-based Cognitive Behavioral Therapy (CBT): Moodgym to help reduce depressive symptoms in repeating undergraduate students at The University of Zambia, Ridgeway campus

This quasi-experimental study demonstrates that the internet-based cognitive behavioral therapy program MoodGYM significantly reduces depressive symptoms among repeating undergraduate students at the University of Zambia, offering a scalable mental health solution for low-resource university settings.

Muleya, C., Paul, R., Ncheka, J., Muchimba, V., Paul, H., Sakala, S., Mukuka, S., Tembo, N. N., Muparuri, T.2026-02-23
📄 psychiatry and clinical psychology

IL-17A, IFN-γ, and MIP-3α Plasma Profiles Predict Clinical Stage Transition in First-Episode Psychosis

This study demonstrates that a plasma cytokine panel, specifically elevated IL-17A combined with lower MIP-3α and IFN-γ levels, serves as a strong predictive biomarker for identifying first-episode psychosis patients at risk of clinical stage transition over a 12-month period.

Rosado, M., Empadinhas, C., Santos, V., Santa, C., Graos, M., Coroa, M., Morais, S., Bajouco, M., Costa, H., Baldeiras (…)2026-02-22
📄 psychiatry and clinical psychology

White Blood Cell Count Shape Heart-Brain Coupling and rTMS Benefit in Depression

This study demonstrates that baseline white blood cell count moderates the relationship between heart-brain coupling during iTBS and clinical improvement in major depression, where higher coupling predicts symptom relief only in patients with lower inflammation, while elevated white blood cell counts are associated with specific white-matter microstructural alterations and reduced treatment efficacy.

Pedraz-Petrozzi, B., Wilkening, J., Sartorius, A., Arns, M., Goya-Maldonado, R.2026-02-21
📄 psychiatry and clinical psychology

Neonatal and Early Childhood Epigenetic Variation Linked to Social and Behavioral Outcomes in Very Preterm Children

This study demonstrates that DNA methylation profiles in very preterm children, particularly during the neonatal period, are significantly associated with social-behavioral outcomes at age 5, implicating specific neurodevelopmental genes and pathways in the biological link between preterm birth and later behavioral challenges.

Patel, P., Huang, Y., Camerota, M., Cragin, C., Carter, B., Check, J., Helderman, J., Hofheimer, J., McGowan, E., Neal (…)2026-02-20
📄 psychiatry and clinical psychology

Cluster-randomized Trial of Homework, Organization, and Planning Skills Program Compared to Treatment as Usual/Waitlist for Youth Ages 11-14: Study Protocol for Conceptual Replication

This study protocol outlines a cluster-randomized trial designed to conceptually replicate the efficacy of the Homework, Organization, and Planning Skills (HOPS) program for youth aged 11–14 by evaluating its effectiveness when delivered by school-based providers compared to treatment-as-usual/waitlist and research team providers under authentic post-pandemic conditions.

Nissley-Tsiopinis, J., Fleming, P. J., Chan, W. J., Langberg, J. M., Cacia, J. J., Vigil, T. J., Chamberlin, B., DiBarto (…)2026-02-17
📄 psychiatry and clinical psychology

Biological embedding of the pyscho-social environment; an Epigenetic Analysis of Adversity from Early-life to Adulthood

This meta-analysis of 227 individuals across three cohorts demonstrates that early-life adversity leaves a common DNA methylation signature involving 15 genes related to neuronal development and metabolism, which can be quantified using a newly developed poly-epigenetic score to track long-term health impacts.

Buchanan, M., Le Cleac'h, J., Meriaux, S. B., Turner, J. D., Mposhi, A.2026-02-16